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CS-W001157 4
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2-Methyl-2-phenylpropaneamine

  • CAS No. 21404-88-6

  • Cat. No. CS-D0358
  • Purity≥95%
  • MDL No.MFCD06213339

*For research and further manufacturing use only, not for direct human use.

2-Methyl-2-phenylpropaneamine|CS-D0358

Structure of 21404-88-6

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General Information

  • CAS No. 21404-88-6
  • Cat. No. CS-D0358
  • Purity ≥95%
  • MDL No. MFCD06213339
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₅N
  • Molecular Weight 149.23
  • Synonym(s) 2-Methyl-2-phenylpropan-1-amine
  • SMILES CC(C1=CC=CC=C1)(C)CN

Description

2-Methyl-2-phenylpropaneamine features a sterically hindered tertiary amine core flanked by a phenyl ring and methyl group, enhancing its stability and reducing nucleophilicity. This structural rigidity facilitates controlled reactivity in synthetic applications, particularly in ligand design and pharmaceutical intermediates. The molecule exhibits favorable solubility in organic solvents and maintains bench-stable integrity under standard handling conditions.

Application

2-Methyl-2-phenylpropaneamine serves as a valuable chiral building block in medicinal chemistry, offering a sterically hindered tertiary amine scaffold. Its stability and ease of purification facilitate use in amine coupling reactions, reductive amination protocols, and as a precursor to bioactive heterocycles. Functions effectively in standard synthetic workflows requiring robust, bench-stable amine intermediates.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 2735
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302+H312+H332-H314
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.9229
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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