2'-O-Methylcytidine

Name: 2'-O-Methylcytidine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 2140-72-9
Cat. No. CS-W012550
Molecule weightNone
Purity≥98%
MDL No.MFCD11519076

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 2140-72-9
Cat. No. CS-W012550
Purity ≥98%
MDL No. MFCD11519076
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₅N₃O₅
Molecular Weight None
Synonym(s) None
SMILES O[C@H]1[C@@H](OC)[C@H](N2C(N=C(N)C=C2)=O)O[C@@H]1CO

Description

For protein-based therapeutics, such as monoclonal antibodies (mAbs) or plasma derived proteins, often highly concentrated protein formulations are required to meet intended dosing regimens. However, this usually comes with elevated viscosities and presents a challenge in the manufacturing process and final formulation. Our Viscosity Reduction Excipient Platform reduces the viscosity and helps overcome challenges associated with highly concentrated protein solutions.As part of our Emprove Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.The Viscosity Reduction Platform is based on the combination of two new excipients, one amino acid component with one anionic component, that together can better reduce protein viscosity beyond levels achieved with single excipients. Also, combining the two components enables a balance of viscosity reduction and protein stabilization. L-Ornithine monohydrochloride Emprove Expert DAB is part of this new proprietary technology platform.

Application

2'-O-Methylcytidine serves as a key nucleoside building block for the synthesis of modified oligonucleotides, enabling enhanced nuclease resistance and improved binding affinity. Its 2'-O-methyl modification provides structural stability and favorable pharmacokinetic properties, making it valuable in antisense therapeutics and RNA-based research applications. The compound exhibits excellent bench stability and compatibility with standard phosphoramidite coupling protocols.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 119.83
LogP -1.9089
H_Acceptors 8
H_Donors 3
Rotatable_Bonds 3

Other Classifications

Life Science Nucleosides & Nucleotides Other Protective Nucleosides

Chemical Biology Pharmaceutical Development and Drug Discovery Research Nucleic Acid Chemistry 2'-O-Methylribonucleosides

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Nucleic Acid Chemistry 2'-O-Methylribonucleosides

Chemical Biology Nucleic Acid Chemistry Protected Nucleosides

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleobases and their Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleoside Analogs

Biochemistry Biochemicals and Reagents Nucleosides, Nucleotides, Oligonucleotides Nucleosides

Key Words

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2'-O-Methylcytidine

CAS No. 2140-72-9

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