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CS-W001157 4
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1,2-Phenylenedimethanamine dihydrochloride

  • CAS No. 21294-14-4

  • Cat. No. CS-0156044
  • Purity≥95%
  • MDL No.MFCD00182462

*For research and further manufacturing use only, not for direct human use.

1,2-Phenylenedimethanamine dihydrochloride|CS-0156044

Structure of 21294-14-4

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General Information

  • CAS No. 21294-14-4
  • Cat. No. CS-0156044
  • Purity ≥95%
  • MDL No. MFCD00182462
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₁₄Cl₂N₂
  • Molecular Weight 209.12
  • Synonym(s) [2-(aminomethyl)phenyl]methanaminedihydrochloride
  • SMILES NCC1=CC=CC=C1CN.[H]Cl.[H]Cl

Description

1,2-Phenylenedimethanamine dihydrochloride delivers a rigid, electron-rich diamine scaffold with enhanced solubility and stability under standard conditions. This bench-stable compound integrates readily into amine-functionalized architectures, enabling efficient coupling in synthetic workflows involving aromatic linkages or polymer backbone construction.

Application

1,2-Phenylenedimethanamine dihydrochloride serves as a versatile bifunctional building block in medicinal chemistry and materials science. Its diamine structure enables efficient incorporation into heterocyclic scaffolds, peptide analogs, and ligand frameworks. The dihydrochloride salt form enhances solubility and stability, facilitating straightforward handling and purification in aqueous or polar organic media. This compound functions effectively in nucleophilic substitution, reductive amination, and amide coupling reactions, supporting scalable synthesis workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   52.04
  • LogP   1.4476
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   2

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