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CS-W001157 4
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3-Chloropyrazine-2-carboxamide

  • CAS No. 21279-62-9

  • Cat. No. CS-W003668
  • Purity≥98%
  • MDL No.MFCD09863915

*For research and further manufacturing use only, not for direct human use.

3-Chloropyrazine-2-carboxamide|CS-W003668

Structure of 21279-62-9

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General Information

  • CAS No. 21279-62-9
  • Cat. No. CS-W003668
  • Purity ≥98%
  • MDL No. MFCD09863915
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₄ClN₃O
  • Molecular Weight 157.56
  • Synonym(s) 3-Chloro-2-pyrazinecarboxaMide
  • SMILES NC(=O)c1nccnc1Cl

Description

3-Chloropyrazine-2-carboxamide is a heterocyclic amide featuring a chlorinated pyrazine core with a carboxamide functionality at the 2-position. This scaffold delivers enhanced electron-withdrawing character and improved metabolic stability, making it valuable for medicinal chemistry applications in kinase inhibitor development and pharmaceutical lead optimization.

Application

3-Chloropyrazine-2-carboxamide serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrazine-based heterocycles through nucleophilic substitution and cross-coupling reactions. Its chlorine and amide functionalities offer orthogonal reactivity for downstream functionalization, while its bench-stable crystalline form facilitates handling and purification in synthetic workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   68.87
  • LogP   0.2289
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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