Lot numbers can be found on the outside label of a product:
1-Oxo-1,2-dihydroisoquinoline-5-carboxylic acid
-
CAS No. 212374-18-0
- Cat. No. CS-0103319
- Purity≥97%
- MDL No.MFCD12024482
*For research and further manufacturing use only, not for direct human use.
Structure of 212374-18-0
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 212374-18-0
- Cat. No. CS-0103319
- Purity ≥97%
- MDL No. MFCD12024482
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₇NO₃
- Molecular Weight 189.17
- Synonym(s) 1-oxo-2H-isoquinoline-5-carboxylic acid
- SMILES O=C(O)C1=CC=CC2=C1C=CNC2=O
Description
1-Oxo-1,2-dihydroisoquinoline-5-carboxylic acid features a fused bicyclic core with a ketone at the C1 position and a carboxylic acid at C5, delivering enhanced stability and polarity. This scaffold integrates readily into bioactive molecule design, particularly in medicinal chemistry campaigns targeting kinase inhibition and CNS-active compounds. The electron-deficient aromatic system supports efficient coupling reactions under standard conditions.
Application
1-Oxo-1,2-dihydroisoquinoline-5-carboxylic acid serves as a versatile scaffold for heterocyclic synthesis, enabling efficient access to isoquinoline-based frameworks relevant in medicinal chemistry. Its carboxylic acid functionality facilitates direct derivatization and conjugation, while the fused ring system offers robust bench stability and compatibility with standard coupling reactions. Functions as a key building block in the construction of bioactive molecules and API intermediates.
Synthesis
-
Route1
-
90947-07-2 - ~85%
-
In-stock
212374-18-0
References
-
Sunderland, Peter T.; Woon, Esther C. Y.; Dhami, Archana; Bergin, Aoife B.; Mahon, Mary F.; Wood, Pauline J.; Jones, Louise A.; Tully, Sophie R.; Lloyd, Matthew D.; Thompson, Andrew S.; Javaid, Hashim; Martin, Niall M. B.; Threadgill, Michael D. Journal of Medicinal Chemistry, 2011 , vol. 54, # 7 p. 2049 - 2059
-
-
Route2
-
2317-22-8 - ~%
-
In-stock
212374-18-0
References
-
Bioorganic and Medicinal Chemistry, , vol. 6, # 6 p. 721 - 734
-
-
Route3
-
212374-17-9 - ~%
-
In-stock
212374-18-0
References
-
Bioorganic and Medicinal Chemistry, , vol. 6, # 6 p. 721 - 734
-
Safety Information
Download SDS|
GHS Pictogram :
N/A
|
GHS No : N/A
|
|
Signal Word : N/A
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : N/A
|
|
|
Precautionary Statements : N/A
|
|
Quality Control
Computational Chemistry Data
- TPSA 70.16
- LogP 1.2263
- H_Acceptors 2
- H_Donors 2
- Rotatable_Bonds 1
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 212374-18-0 sigma212374-18-0 manufacturer212374-18-0 price212374-18-0 structure212374-18-0 SDSbuy 212374-18-0212374-18-0 supplier212374-18-0 uses212374-18-0 molecular weightprice of 212374-18-0212374-18-0 chemical name formula of 212374-18-0