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(3-Fluorobicyclo[1.1.1]pentan-1-yl)methanamine hydrochloride

  • CAS No. 2108917-20-8

  • Cat. No. CS-0370304
  • Molecule weight151.61
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(3-Fluorobicyclo[1.1.1]pentan-1-yl)methanamine hydrochloride|CS-0370304

Structure of 2108917-20-8

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General Information

  • CAS No. 2108917-20-8
  • Cat. No. CS-0370304
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature, keep dry and cool
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₁ClFN
  • Molecular Weight 151.61
  • Synonym(s) (3-Fluoro-1-bicyclo[1.1.1]pentanyl)methanamine hydrochloride
  • SMILES NCC1(C2)CC2(F)C1.[H]Cl

Description

This bicyclic amine scaffold delivers a rigid, sterically constrained platform for medicinal chemistry optimization. The fluorinated cage imparts enhanced metabolic stability and modulates electronic properties, while the primary amine functionality enables straightforward conjugation. A bench-stable, moisture-tolerant building block for targeted ligand design.

Application

(3-Fluorobicyclo[1.1.1]pentan-1-yl)methanamine hydrochloride serves as a rigid, conformationally constrained amine building block for medicinal chemistry and target-oriented synthesis. Its trifluoromethyl-like steric profile and enhanced metabolic stability facilitate incorporation into bioactive molecules. The hydrochloride salt ensures excellent solubility and bench stability, enabling straightforward handling in standard amine coupling and reductive amination protocols.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   1.2591
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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