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CS-W001157 4
Total: USD 88.00

2-Chloro-4-fluoroaniline

  • CAS No. 2106-02-7

  • Cat. No. CS-0017181
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Chloro-4-fluoroaniline|CS-0017181

Structure of 2106-02-7

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General Information

  • CAS No. 2106-02-7
  • Cat. No. CS-0017181
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₅ClFN
  • Molecular Weight 145.56
  • Synonym(s) CHLOROFLUOROANILINE
  • SMILES NC1=CC=C(F)C=C1Cl

Description

2-Chloro-4-fluoroaniline features a strategically positioned chloro and fluoro substituent on the aniline ring, enabling selective functionalization in pharmaceutical intermediates. This electron-deficient aromatic amine integrates readily into coupling reactions, offering enhanced reactivity under standard conditions.

Application

2-Chloro-4-fluoroaniline serves as a valuable building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to substituted anilines via palladium-catalyzed cross-coupling reactions. Its ortho-chloro and para-fluoro substituents provide complementary reactivity for sequential functionalization, while the amine group offers direct handle for derivatization. The compound exhibits good bench stability and facilitates straightforward purification, making it well-suited for multi-step synthesis workflows.

Synthesis

  • Route1
    • null|null
      371-40-4
    • ~86%
    • In-stock
      2-Chloro-4-fluoroaniline|CS-0017181
      2106-02-7

    References

    • Stoll, Armin H.; Knochel, Paul Organic Letters, 2008 , vol. 10, # 1 p. 113 - 116
  • Route2

    References

    • Journal of the American Chemical Society, , vol. 81, p. 94,95, 97
  • Route3
    • null|null
      88-73-3
    • ~36%
    • In-stock
      2-Chloro-4-fluoroaniline|CS-0017181
      2106-02-7
    • null|null
      95-51-2

    References

    • Tordeux, Marc; Wakselman, Claude Journal of Fluorine Chemistry, 1995 , vol. 74, # 2 p. 251 - 254

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   2.0613
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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