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CS-W001157 4
Total: USD 88.00

4-(4-chlorophenyl)thiazol-2-amine

  • CAS No. 2103-99-3

  • Cat. No. CS-0044969
  • Purity≥98%
  • MDL No.MFCD00047058

*For research and further manufacturing use only, not for direct human use.

4-(4-chlorophenyl)thiazol-2-amine|CS-0044969

Structure of 2103-99-3

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General Information

  • CAS No. 2103-99-3
  • Cat. No. CS-0044969
  • Purity ≥98%
  • MDL No. MFCD00047058
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₇ClN₂S
  • Molecular Weight 210.68
  • Synonym(s) None
  • SMILES ClC1=CC=C(C2=CSC(N)=N2)C=C1

Description

2-Amino-4-(4-chlorophenyl)thiazole was used in the preparation of 2-chloroacetamido-4-(4-chlorophenyl)thiazole.

Application

4-(4-Chlorophenyl)thiazol-2-amine serves as a versatile building block in medicinal chemistry, enabling the synthesis of thiazole-based bioactive molecules. Its well-defined reactivity facilitates palladium-catalyzed cross-coupling reactions and functionalization at the 2-position. The chlorophenyl moiety provides a handle for further derivatization, while the thiazole scaffold offers metabolic stability and favorable pharmacokinetic properties. Bench-stable and readily purified, it functions reliably in standard synthetic workflows for API development.

Synthesis

  • Route1
    • null|null
      17356-08-0
    • In-stock
      2-Bromo-1-(4-chlorophenyl)ethanone|CS-W014171
      536-38-9
    • ~96%
    • In-stock
      4-(4-chlorophenyl)thiazol-2-amine|CS-0044969
      2103-99-3

    References

    • Banothu, Janardhan; Vaarla, Krishnaiah; Bavantula, Rajitha; Crooks, Peter A. Chinese Chemical Letters, 2014 , vol. 25, # 1 p. 172 - 175
  • Route2
    • null|null
      99-91-2
    • null|null
      17356-08-0
    • ~97%
    • In-stock
      4-(4-chlorophenyl)thiazol-2-amine|CS-0044969
      2103-99-3

    References

    • Pandeya; Sriram; Nath; Declercq European Journal of Pharmaceutical Sciences, 1999 , vol. 9, # 1 p. 25 - 31
  • Route3
    • null|null
      53896-48-3
    • null|null
      17356-08-0
    • ~%
    • In-stock
      4-(4-chlorophenyl)thiazol-2-amine|CS-0044969
      2103-99-3

    References

    • Tetrahedron, , vol. 68, # 1 p. 173 - 178

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   3.0457
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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