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CS-W001157 4
Total: USD 88.00

(1-(tert-Butoxycarbonyl)-1H-indol-4-yl)boronic acid

  • CAS No. 2102451-30-7

  • Cat. No. CS-0162400
  • Purity≥98%
  • MDL No.MFCD28130132

*For research and further manufacturing use only, not for direct human use.

(1-(tert-Butoxycarbonyl)-1H-indol-4-yl)boronic acid|CS-0162400

Structure of 2102451-30-7

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General Information

  • CAS No. 2102451-30-7
  • Cat. No. CS-0162400
  • Purity ≥98%
  • MDL No. MFCD28130132
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₃H₁₆BNO₄
  • Molecular Weight 261.08
  • Synonym(s) N-BOC-indole-4-boronic acid
  • SMILES O=C(N1C=CC2=C1C=CC=C2B(O)O)OC(C)(C)C

Description

This boronate moiety integrates readily into Suzuki-Miyaura couplings, delivering indole-based architectures with high functional group tolerance. The tert-butyl carbamate protection ensures stability during storage and handling, enabling straightforward deprotection to reveal the free amine under mild acidic conditions.

Application

(1-(tert-Butoxycarbonyl)-1H-indol-4-yl)boronic acid serves as a stable, bench-ready building block for Suzuki-Miyaura cross-coupling reactions. The Boc-protected indole moiety enables orthogonal functionalization and facilitates purification, while the boronic acid group exhibits high reactivity with aryl halides under mild conditions. This compound is particularly valuable in constructing complex indole-containing scaffolds relevant to medicinal chemistry and materials science.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   71.69
  • LogP   1.1043
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   1

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