Lot numbers can be found on the outside label of a product:
2-Hydroxy-5-(trifluoromethyl)benzaldehyde
-
CAS No. 210039-65-9
- Cat. No. CS-0131313
- Purity≥98%
- MDL No.MFCD16999709
*For research and further manufacturing use only, not for direct human use.
Structure of 210039-65-9
Please choose your location and provide accurate information for you
| Size |
|
Price | Quantity | |||
|---|---|---|---|---|---|---|
|
* Please select Quantity before adding items. |
||||||
Recommended Products
General Information
- CAS No. 210039-65-9
- Cat. No. CS-0131313
- Purity ≥98%
- MDL No. MFCD16999709
- Storage 4°C, stored under nitrogen
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₅F₃O₂
- Molecular Weight 190.12
- Synonym(s) 2-hydroxy-4-trifluoromethyl benzaldehyde
- SMILES O=CC1=CC(C(F)(F)F)=CC=C1O
Description
2-Hydroxy-5-(trifluoromethyl)benzaldehyde features a strategically positioned trifluoromethyl group that enhances electron-withdrawal and metabolic stability, while the adjacent phenolic hydroxyl enables hydrogen bonding and coordination in catalytic systems. This combination imparts unique reactivity in transition metal-catalyzed couplings and serves as a key building block in bioactive molecule synthesis.
Application
2-Hydroxy-5-(trifluoromethyl)benzaldehyde serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling efficient access to substituted benzoxazole and benzothiazole scaffolds. Its ortho-hydroxyl and trifluoromethyl groups confer enhanced electronic modulation and metabolic stability, while the aldehyde functionality supports diverse transformations including reductive amination, nucleophilic addition, and condensation reactions. Bench-stable and readily purified by recrystallization, it functions reliably in standard synthetic workflows.
Synthesis
-
Route1
-
402-45-9 -
100-97-0 - ~33%
-
In-stock
210039-65-9
References
-
Lin, Xu; Doyle, Terrence W.; King, Ivan Patent: US2004/254103 A1, 2004 ; Location in patent: Page 9 ;
-
-
Route2
-
134142-88-4
- ~%
-
In-stock
210039-65-9
References
-
NSAB, FILIAL AF NEUROSEARCH SWEDEN AB, SVERIGE Patent: WO2009/133109 A1, 2009 ; Location in patent: Page/Page column 54 ;
-
-
Route3
-
134142-88-4
-
68-12-2
- ~77%
-
In-stock
210039-65-9
References
-
Geneste; Schaefer Synthesis, 2001 , # 15 p. 2259 - 2262
-
Safety Information
Download SDS|
GHS Pictogram :
|
GHS No : GHS07
|
|
Signal Word : Warning
|
UN#: N/A
|
|
Class : N/A
|
Packing Group : N/A
|
|
Hazard Statements : H302
|
|
|
Precautionary Statements : P261-P280-P304+P340-P405
|
|
Quality Control
Computational Chemistry Data
- TPSA 37.3
- LogP 2.2235
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 1
Similar Products
Other Classifications
Recently Viewed Products
Leave US a Message
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Upload Pictures
|
|
Key Words
- 210039-65-9 sigma210039-65-9 manufacturer210039-65-9 price210039-65-9 structure210039-65-9 SDSbuy 210039-65-9210039-65-9 supplier210039-65-9 uses210039-65-9 molecular weightprice of 210039-65-9210039-65-9 chemical name formula of 210039-65-9