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CS-W001157 4
Total: USD 88.00

2-(Chloromethyl)pyrazine hydrochloride

  • CAS No. 210037-98-2

  • Cat. No. CS-W021436
  • Purity≥98%
  • MDL No.MFCD16988430

*For research and further manufacturing use only, not for direct human use.

2-(Chloromethyl)pyrazine hydrochloride|CS-W021436

Structure of 210037-98-2

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General Information

  • CAS No. 210037-98-2
  • Cat. No. CS-W021436
  • Purity ≥98%
  • MDL No. MFCD16988430
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₆Cl₂N₂
  • Molecular Weight 165.02
  • Synonym(s) 2-(Chloromethyl)pyrazine HCL
  • SMILES ClCC1=NC=CN=C1.[H]Cl

Description

This chloromethylpyrazine derivative delivers a reactive handle for nucleophilic substitution, enabling efficient conjugation in synthetic and medicinal chemistry. The hydrochloride salt enhances solubility and stability under standard conditions, facilitating use in multistep syntheses and bioconjugation workflows.

Application

2-(Chloromethyl)pyrazine hydrochloride serves as a versatile electrophilic building block for the site-selective introduction of pyrazinyl moieties in synthetic workflows. Its chloromethyl group enables efficient nucleophilic substitution with amines, thiols, and other heteroatom nucleophiles under mild conditions, facilitating rapid access to functionalized pyrazine derivatives. The hydrochloride salt enhances solubility and stability in polar solvents, simplifying handling and purification—ideal for medicinal chemistry campaigns and API intermediate synthesis.

Safety Information

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GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 3261
Class : 8
Packing Group : Ⅲ
Hazard Statements : H302+H312-H314
Precautionary Statements : P260-P264-P270-P280-P301+P330+P331-P330-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   25.78
  • LogP   1.6372
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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