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CS-W001157 4
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4-Chloro-2-methylphenylboronic acid

  • CAS No. 209919-30-2

  • Cat. No. CS-W017681
  • Purity≥98%
  • MDL No.MFCD02683107

*For research and further manufacturing use only, not for direct human use.

4-Chloro-2-methylphenylboronic acid|CS-W017681

Structure of 209919-30-2

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General Information

  • CAS No. 209919-30-2
  • Cat. No. CS-W017681
  • Purity ≥98%
  • MDL No. MFCD02683107
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₈BClO₂
  • Molecular Weight 170.40
  • Synonym(s) 4-Chloro-o-tolylboronic Acid (contains varying amounts of Anhydride)
  • SMILES ClC1=CC(=C(C=C1)B(O)O)C

Description

4-Chloro-2-methylphenylboronic acid features a boronate moiety attached to a chlorinated, methyl-substituted aromatic ring, enabling efficient Suzuki-Miyaura cross-coupling reactions. This bench-stable reagent integrates seamlessly into complex molecule synthesis, particularly in pharmaceutical and agrochemical development workflows.

Application

4-Chloro-2-methylphenylboronic acid serves as a versatile building block in Suzuki-Miyaura cross-coupling reactions, enabling efficient C–C bond formation under mild conditions. Its stability, ease of handling, and compatibility with diverse functional groups make it well-suited for the synthesis of substituted biaryls and complex heterocycles in medicinal chemistry and materials science applications.

Synthesis

  • Route1

    References

    • KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; OSCOTEC INC. Patent: WO2005/123054 A1, 2005 ; Location in patent: Page/Page column 23 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   0.32822
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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