(R)-Azetidin-2-ylmethanol

Name: (R)-Azetidin-2-ylmethanol
Brand: ChemScene
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CAS No. 209329-11-3
Cat. No. CS-0053482
Molecule weight87.12
Purity≥98%
MDL No.MFCD10565789

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Structure of 209329-11-3

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General Information

CAS No. 209329-11-3
Cat. No. CS-0053482
Purity ≥98%
MDL No. MFCD10565789
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₄H₉NO
Molecular Weight 87.12
Synonym(s) None
SMILES OC[C@H]1CCN1

Description

(R)-Azetidin-2-ylmethanol is a chiral building block featuring a stereodefined azetidine ring fused to a primary alcohol group. This configuration enables selective incorporation into bioactive molecules, particularly in medicinal chemistry campaigns targeting CNS-active compounds. The molecule exhibits favorable solubility and stability under standard handling conditions.

Application

(R)-Azetidin-2-ylmethanol serves as a valuable chiral building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard functional group manipulations. Its bench-stable nature and tolerance to diverse reaction conditions facilitate straightforward incorporation into complex molecules. The stereogenic center supports enantioselective transformations, making it particularly useful for constructing azetidine-containing scaffolds prevalent in pharmaceutical development.

Synthesis

Route1
- In-stock
  
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- ~%
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  209329-11-3
References
- Lynch, John K.; Holladay, Mark W.; Ryther, Keith B.; Bai, Hao; Hsiao, Chi-Nung; Morton, Howard E.; Dickman, Daniel A.; Arnold, William; King, Steven A. Tetrahedron Asymmetry, 1998 , vol. 9, # 16 p. 2791 - 2794

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 32.26
LogP -0.6594
H_Acceptors 2
H_Donors 2
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Azetidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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(R)-Azetidin-2-ylmethanol

CAS No. 209329-11-3

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