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CS-W001157 4
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2-Iodo-3-pyridinamine

  • CAS No. 209286-97-5

  • Cat. No. CS-W019772
  • Purity≥97%
  • MDL No.MFCD07779506

*For research and further manufacturing use only, not for direct human use.

2-Iodo-3-pyridinamine|CS-W019772

Structure of 209286-97-5

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General Information

  • CAS No. 209286-97-5
  • Cat. No. CS-W019772
  • Purity ≥97%
  • MDL No. MFCD07779506
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₅IN₂
  • Molecular Weight 220.01
  • Synonym(s) 2-Iodopyridin-3-ylamine
  • SMILES NC1=CC=CN=C1I

Description

2-Iodo-3-pyridinamine delivers a reactive iodide handle and a pyridinamine moiety for cross-coupling and functionalization. The electron-deficient pyridine ring enhances reactivity in palladium-catalyzed transformations, while the amine group offers anchoring points for conjugation. This bench-stable compound integrates seamlessly into complex molecule synthesis.

Application

2-Iodo-3-pyridinamine serves as a versatile building block for palladium-catalyzed cross-coupling reactions, enabling efficient construction of biaryl and heteroaryl scaffolds. Its iodine group facilitates reliable coupling with boranes, stannanes, and other nucleophiles under standard conditions, while the pyridinamine functionality offers orthogonal reactivity for further derivatization. Bench-stable and readily purified by crystallization or chromatography, it functions effectively in medicinal chemistry campaigns requiring modular heterocycle assembly.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   38.91
  • LogP   1.2684
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   0

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