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Structure of 2089649-11-4
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6-(Trifluoromethyl)quinoline-8-carboxylic acid combines a trifluoromethyl group with a quinoline scaffold, delivering enhanced electron-withdrawing character and metabolic stability. This rigid, planar architecture supports integration into bioactive scaffolds, enabling efficient coupling in medicinal chemistry campaigns. The carboxylic acid functionality facilitates direct derivatization or salt formation for improved solubility and handling under standard conditions.
6-(Trifluoromethyl)quinoline-8-carboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling direct incorporation into pharmaceutical scaffolds via amide coupling or decarboxylative functionalization. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the carboxylic acid facilitates conjugation in peptide and macrocyclic systems. Its bench-stable nature and compatibility with standard coupling reagents make it ideal for medicinal chemistry campaigns requiring fluorinated quinoline motifs.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P280-P302+P352
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Lot numbers can be found on the outside label of a product: