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CS-W001157 4
Total: USD 88.00

6-(Trifluoromethyl)quinoline-8-carboxylic acid

  • CAS No. 2089649-11-4

  • Cat. No. CS-0528603
  • Molecule weight241.17
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-(Trifluoromethyl)quinoline-8-carboxylic acid|CS-0528603

Structure of 2089649-11-4

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General Information

  • CAS No. 2089649-11-4
  • Cat. No. CS-0528603
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₆F₃NO₂
  • Molecular Weight 241.17
  • Synonym(s) None
  • SMILES O=C(C1=C2N=CC=CC2=CC(C(F)(F)F)=C1)O

Description

6-(Trifluoromethyl)quinoline-8-carboxylic acid combines a trifluoromethyl group with a quinoline scaffold, delivering enhanced electron-withdrawing character and metabolic stability. This rigid, planar architecture supports integration into bioactive scaffolds, enabling efficient coupling in medicinal chemistry campaigns. The carboxylic acid functionality facilitates direct derivatization or salt formation for improved solubility and handling under standard conditions.

Application

6-(Trifluoromethyl)quinoline-8-carboxylic acid serves as a versatile building block for heterocyclic synthesis, enabling direct incorporation into pharmaceutical scaffolds via amide coupling or decarboxylative functionalization. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the carboxylic acid facilitates conjugation in peptide and macrocyclic systems. Its bench-stable nature and compatibility with standard coupling reagents make it ideal for medicinal chemistry campaigns requiring fluorinated quinoline motifs.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   50.19
  • LogP   2.9518
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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