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CS-W001157 4
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4-Hydroxy-N,N-dimethylbenzamide

  • CAS No. 20876-99-7

  • Cat. No. CS-0138027
  • Purity≥98%
  • MDL No.MFCD01168919

*For research and further manufacturing use only, not for direct human use.

4-Hydroxy-N,N-dimethylbenzamide|CS-0138027

Structure of 20876-99-7

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General Information

  • CAS No. 20876-99-7
  • Cat. No. CS-0138027
  • Purity ≥98%
  • MDL No. MFCD01168919
  • Storage RT, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₁NO₂
  • Molecular Weight 165.19
  • Synonym(s) OTAVA-BB 0117380127
  • SMILES O=C(N(C)C)C1=CC=C(O)C=C1

Description

4-Hydroxy-N,N-dimethylbenzamide features a phenolic hydroxyl group flanked by an electron-rich dimethylamino moiety, enabling robust hydrogen bonding and enhanced solubility in polar solvents. This structural combination supports efficient incorporation into bioconjugation workflows and peptide derivatization, where stability under standard conditions is critical.

Application

4-Hydroxy-N,N-dimethylbenzamide serves as a versatile building block in medicinal chemistry, enabling direct incorporation of phenolic and amide functionalities into target molecules. Its bench-stable nature and compatibility with standard coupling protocols facilitate efficient synthesis of complex scaffolds. The hydroxyl group offers a reliable handle for derivatization, while the N,N-dimethylamide moiety provides enhanced metabolic stability and lipophilicity, making it well-suited for API development workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   40.54
  • LogP   1.094
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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