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CS-W001157 4
Total: USD 88.00

2-Chloro-6-(hydroxymethyl)pyridin-3-ol

  • CAS No. 208519-41-9

  • Cat. No. CS-0060367
  • Purity≥95%
  • MDL No.MFCD12922671

*For research and further manufacturing use only, not for direct human use.

2-Chloro-6-(hydroxymethyl)pyridin-3-ol|CS-0060367

Structure of 208519-41-9

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General Information

  • CAS No. 208519-41-9
  • Cat. No. CS-0060367
  • Purity ≥95%
  • MDL No. MFCD12922671
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₆ClNO₂
  • Molecular Weight 159.57
  • Synonym(s) 2-Chloro-6-(hydroxymethyl)-3-pyridinol
  • SMILES C1=CC(=C(Cl)N=C1CO)O

Description

2-Chloro-6-(hydroxymethyl)pyridin-3-ol features a pyridine core functionalized with a chlorine atom and a hydroxymethyl group, enabling selective derivatization. The phenolic hydroxyl supports hydrogen bonding and enhances solubility, while the electron-withdrawing chlorine imparts reactivity for cross-coupling or nucleophilic substitution. This bench-stable scaffold integrates readily into bioactive molecule synthesis.

Application

2-Chloro-6-(hydroxymethyl)pyridin-3-ol serves as a versatile building block in medicinal chemistry, enabling efficient access to pyridine-based pharmacophores. The molecule combines a reactive chloro group for nucleophilic substitution and a pendant hydroxymethyl function for oxidation or derivatization. Its bench-stable nature and compatibility with standard coupling protocols facilitate streamlined synthesis of heterocyclic intermediates and API candidates.

Synthesis

  • Route1
    • null|null
      50-00-0
    • In-stock
      2-Chloro-3-pyridinol|CS-D0978
      6636-78-8
    • ~83%
    • In-stock
      2-Chloro-6-(hydroxymethyl)pyridin-3-ol|CS-0060367
      208519-41-9

    References

    • Exelixis, Inc. Patent: US2010/249071 A1, 2010 ; Location in patent: Page/Page column 41-42 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   53.35
  • LogP   0.9329
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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