(2-Chloro-4-fluorophenyl)methanol

Name: (2-Chloro-4-fluorophenyl)methanol
Brand: ChemScene
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CAS No. 208186-84-9
Cat. No. CS-W017935
Purity≥98%
MDL No.MFCD00236024

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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(2-Chloro-4-fluorophenyl)methanol|CS-W017935

Structure of 208186-84-9

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General Information

CAS No. 208186-84-9
Cat. No. CS-W017935
Purity ≥98%
MDL No. MFCD00236024
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₆ClFO
Molecular Weight 160.57
Synonym(s) Benzenemethanol, 2-chloro-4-fluoro-
SMILES OCC1=C(Cl)C=C(F)C=C1

Description

(2-Chloro-4-fluorophenyl)methanol is a bench-stable, moisture-tolerant aryl alcohol featuring orthogonal halogen substituents that enable selective functionalization. This electron-deficient phenyl scaffold integrates readily into synthetic intermediates for pharmaceuticals and agrochemicals, offering predictable reactivity in nucleophilic substitution and coupling processes under standard conditions.

Application

(2-Chloro-4-fluorophenyl)methanol serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated aromatic scaffolds. Its benzylic alcohol functionality facilitates direct oxidation to carboxylic acids or conversion to esters and ethers under standard conditions. The molecule exhibits good bench stability and compatibility with common protecting group strategies, supporting its use in multi-step synthesis of bioactive compounds and heterocyclic systems.

Synthesis

Route1
- In-stock
  
  85953-29-3
- ~91%
- In-stock
  
  208186-84-9
References
- Boechat, Nubia; Santos Da Costa, Jorge Carlos; De Souza Mendonca, Jorge; Mello De Oliveira, Pedro Santos; Nora De Souza, Marcus Vinicius Tetrahedron Letters, 2004 , vol. 45, # 31 p. 6021 - 6022
Route2
- In-stock
  
  2252-51-9
- ~%
- In-stock
  
  208186-84-9
References
- US6348474 B1, ; Page column 125 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P302+P352-P304+P340

Quality Control

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Computational Chemistry Data

TPSA 20.23
LogP 1.9714
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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(2-Chloro-4-fluorophenyl)methanol

CAS No. 208186-84-9

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