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CS-W001157 4
Total: USD 88.00

1-Bromo-2,3-difluoro-4-iodo-benzene

  • CAS No. 207989-04-6

  • Cat. No. CS-0183178
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Bromo-2,3-difluoro-4-iodo-benzene|CS-0183178

Structure of 207989-04-6

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General Information

  • CAS No. 207989-04-6
  • Cat. No. CS-0183178
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₂BrF₂I
  • Molecular Weight 318.89
  • Synonym(s) 4-Bromo-2,3-difluoroiodobenzene
  • SMILES C1=CC(=C(C(=C1Br)F)F)I

Description

1-Bromo-2,3-difluoro-4-iodo-benzene features a highly functionalized aromatic core with halogens at strategic positions, enabling precise cross-coupling reactions. The combination of bromo, difluoro, and iodo substituents offers orthogonal reactivity for sequential transformations. This electron-deficient scaffold integrates readily into complex molecular architectures under standard palladium-catalyzed conditions.

Application

1-Bromo-2,3-difluoro-4-iodo-benzene serves as a versatile polyhalogenated aromatic building block for transition-metal-catalyzed cross-coupling reactions. The strategic placement of bromo, difluoro, and iodo substituents enables sequential functionalization via orthogonal reactivity, facilitating the construction of complex fluorinated arenes. Bench-stable and compatible with Pd- and Ni-catalyzed coupling protocols, it offers predictable regioselectivity and efficient purification, making it well-suited for medicinal chemistry and materials science applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H320-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   0
  • LogP   3.3319
  • H_Acceptors   0
  • H_Donors   0
  • Rotatable_Bonds   0

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