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CS-W001157 4
Total: USD 88.00

1-(2-Hydroxyethyl)urea

  • CAS No. 2078-71-9

  • Cat. No. CS-W011301
  • Purity≥98%
  • MDL No.MFCD00059080

*For research and further manufacturing use only, not for direct human use.

1-(2-Hydroxyethyl)urea|CS-W011301

Structure of 2078-71-9

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General Information

  • CAS No. 2078-71-9
  • Cat. No. CS-W011301
  • Purity ≥98%
  • MDL No. MFCD00059080
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃H₈N₂O₂
  • Molecular Weight 104.11
  • Synonym(s) β-Hydroxyethylurea
  • SMILES O=C(N)NCCO

Description

1-(2-Hydroxyethyl)urea is a polar, bench-stable compound featuring a hydroxyl group adjacent to a urea moiety. This dual functionality enhances solubility in aqueous and protic solvents while enabling hydrogen bonding interactions. The molecule integrates readily into synthesis pathways requiring both nucleophilic and hydrogen-bond-donating capabilities, particularly in peptide coupling and polymer functionalization.

Application

1-(2-Hydroxyethyl)urea serves as a versatile bifunctional building block in synthetic chemistry, enabling the construction of heterocyclic scaffolds and bioactive molecules. Its hydroxyl and urea functionalities offer orthogonal reactivity for derivatization, while demonstrating excellent bench stability and ease of purification. The compound functions effectively in nucleophilic substitution and condensation reactions, facilitating access to diverse molecular architectures relevant to medicinal chemistry and materials science.

Synthesis

  • Route1
    • null|null
      590-28-3
    • null|null
      141-43-5
    • ~82%
    • In-stock
      1-(2-Hydroxyethyl)urea|CS-W011301
      2078-71-9

    References

    • Kravchenko; Maksareva; Belyakov; Sigachev; Chegaev; Lyssenko; Lebedev; Makhova Russian Chemical Bulletin, 2003 , vol. 52, # 1 p. 192 - 197
  • Route2
    • Ethanolamine hydrochloride|CS-0088236
      2002-24-6
    • null|null
      151-50-8
    • ~68%
    • In-stock
      1-(2-Hydroxyethyl)urea|CS-W011301
      2078-71-9

    References

    • Miyahara; Nakadate; Kamiya Chemical and Pharmaceutical Bulletin, 1985 , vol. 33, # 2 p. 497 - 502
  • Route3
    • null|null
      556-89-8
    • null|null
      141-43-5
    • ~86%
    • In-stock
      1-(2-Hydroxyethyl)urea|CS-W011301
      2078-71-9

    References

    • Uhlmann, Eugen; Pfleiderer, Wolfgang Heterocycles, 1981 , vol. 15, # 1 p. 437 - 453

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   75.35
  • LogP   -1.353
  • H_Acceptors   2
  • H_Donors   3
  • Rotatable_Bonds   2

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