Lot numbers can be found on the outside label of a product:
tert-Butyl 4-bromopyridin-2-ylcarbamate
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CAS No. 207799-10-8
- Cat. No. CS-0030415
- Purity≥96%
- MDL No.MFCD09037866
*For research and further manufacturing use only, not for direct human use.
Structure of 207799-10-8
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General Information
- CAS No. 207799-10-8
- Cat. No. CS-0030415
- Purity ≥96%
- MDL No. MFCD09037866
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₁₃BrN₂O₂
- Molecular Weight 273.13
- Synonym(s) tert-Butyl (4-bromopyridin-2-yl)carbamate
- SMILES O=C(OC(C)(C)C)NC1=NC=CC(Br)=C1
Description
tert-Butyl 4-bromopyridin-2-ylcarbamate features a brominated pyridine core with a robust tert-butyl carbamate protecting group, enabling stable incorporation of the pyridinyl moiety in synthetic sequences. This bench-stable reagent facilitates efficient coupling and functionalization under standard conditions.
Application
tert-Butyl 4-bromopyridin-2-ylcarbamate serves as a versatile building block in medicinal chemistry, enabling direct functionalization at the pyridine C4 position via cross-coupling reactions. The carbamate group provides excellent stability under basic conditions and facilitates selective deprotection to yield the free amine. Its compatibility with palladium-catalyzed transformations and tolerance for diverse functional groups make it ideal for constructing complex heterocyclic scaffolds in API development.
Synthesis
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Route1
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75-65-0 - ~66%
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In-stock
207799-10-8
References
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Bristol-Myers Squibb Company Patent: US2008/9465 A1, 2008 ; Location in patent: Page/Page column 44 ; US 20080009465 A1
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Route2
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In-stock
30766-03-1 - ~92%
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In-stock
207799-10-8
References
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CURIS, INC. Patent: WO2008/57497 A2, 2008 ; Location in patent: Page/Page column 293 ;
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References
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WO2014/418 A1, ; Page/Page column 30; 31 ;
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 51.22
- LogP 3.1911
- H_Acceptors 3
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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