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CS-W001157 4
Total: USD 88.00

Fmoc-Glu-O-2-PhiPr

  • CAS No. 207305-97-3

  • Cat. No. CS-0201737
  • Molecule weight487.54
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Fmoc-Glu-O-2-PhiPr|CS-0201737

Structure of 207305-97-3

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General Information

  • CAS No. 207305-97-3
  • Cat. No. CS-0201737
  • Purity ≥97%
  • MDL No. None
  • Storage Sealed in dry,2-8℃
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₉H₂₉NO₆
  • Molecular Weight 487.54
  • Synonym(s) None
  • SMILES CC(C)(C1=CC=CC=C1)OC(=O)[C@H](CCC(=O)O)NC(=O)OCC2C3=C(C=CC=C3)C4=C2C=CC=C4

Description

Alkyne-A-DSBSO (alkyne-tagged, acid-cleavable disuccinimidyl bissulfoxide) Crosslinker is a homobifunctional, membrane-permeable, enrichable disulfoxide-containing crosslinker for analysis of protein-protein interactions (PPIs) through crosslinking mass spectrometry (XL-MS). Alkyne-A-DSBSO possesses two N-hydroxysuccinimide (NHS) ester groups for targeting amines, a 14 spacer length, two symmetrical acid-cleavable C-S bonds, and a central bioorthogonal azide tag. After reacting with lysine (Lys) residues, the alkyne tag permits selective enrichment of crosslinked proteins or peptides with a biotin-conjugated azide probe to enhance their detection. Additionally, the post-cleavage spacer yields tagged peptides for unambiguous identification by collision-induced dissociation in tandem MS. Alkyne-A-DSBSO Crosslinker has mapped in vivo PPIs for target protein complexes and whole proteomes from living cells. It will also be a useful proteomics tool in the quest for targeting undruggable protein targets.

Safety Information

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Computational Chemistry Data

  • TPSA   101.93
  • LogP   5.237
  • H_Acceptors   5
  • H_Donors   2
  • Rotatable_Bonds   9

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