4-Amino-2,6-difluorobenzonitrile

Name: 4-Amino-2,6-difluorobenzonitrile
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CAS No. 207297-92-5
Cat. No. CS-0199689
Purity≥95%
MDL No.MFCD03407466

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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4-Amino-2,6-difluorobenzonitrile|CS-0199689

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General Information

CAS No. 207297-92-5
Cat. No. CS-0199689
Purity ≥95%
MDL No. MFCD03407466
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₇H₄F₂N₂
Molecular Weight 154.12
Synonym(s) Benzonitrile, 4-amino-2,6-difluoro- (9CI)
SMILES C1=C(C=C(C(=C1F)C#N)F)N

Description

4-Amino-2,6-difluorobenzonitrile features a strategically positioned amino group flanked by two fluorine atoms and a nitrile moiety, enabling robust coupling reactions in synthetic medicinal chemistry. This electron-deficient scaffold integrates readily into complex heterocycles and serves as a key building block for kinase inhibitors and advanced pharmaceutical intermediates under standard conditions.

Application

4-Amino-2,6-difluorobenzonitrile serves as a versatile building block in medicinal chemistry, enabling efficient access to fluorinated heterocycles and bioactive scaffolds. Its amino and nitrile groups provide orthogonal reactivity for downstream functionalization, while the difluoro substitution enhances metabolic stability and modulates electronic properties. Bench-stable and readily purified, it facilitates robust coupling reactions and is compatible with standard synthetic workflows in API development.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

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Computational Chemistry Data

TPSA 49.81
LogP 1.41868
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Cyanide/Nitrile

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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4-Amino-2,6-difluorobenzonitrile

CAS No. 207297-92-5

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