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CS-W001157 4
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(S)-3-((tert-Butyldimethylsilyl)oxy)pyrrolidine

  • CAS No. 207113-36-8

  • Cat. No. CS-0154946
  • Purity≥96%
  • MDL No.MFCD09909497

*For research and further manufacturing use only, not for direct human use.

(S)-3-((tert-Butyldimethylsilyl)oxy)pyrrolidine|CS-0154946

Structure of 207113-36-8

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General Information

  • CAS No. 207113-36-8
  • Cat. No. CS-0154946
  • Purity ≥96%
  • MDL No. MFCD09909497
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₂₃NOSi
  • Molecular Weight 201.38
  • Synonym(s) Pyrrolidine, 3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-, (3S)-
  • SMILES CC(C)(C)[Si](C)(C)O[C@H]1CCNC1

Description

(S)-3-((tert-Butyldimethylsilyl)oxy)pyrrolidine features a stereodefined pyrrolidine core protected at the 3-hydroxyl position by a bulky silyl group, providing exceptional stability and compatibility in complex synthesis. This derivative enables reliable incorporation into chiral scaffolds under standard conditions, streamlining access to functionalized heterocycles without racemization.

Application

(S)-3-((tert-Butyldimethylsilyl)oxy)pyrrolidine serves as a stable, bench-ready chiral building block for the synthesis of pyrrolidine-containing scaffolds. The silyl ether group provides excellent protection for the hydroxyl functionality, enabling orthogonal handling in complex sequences. It reacts cleanly with electrophiles and participates reliably in standard coupling and cyclization protocols, facilitating efficient access to medicinally relevant heterocycles.

Safety Information

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GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H227-H302-H315-H317-H318-H335
Precautionary Statements : P210-P261-P264-P270-P271-P272-P280-P302+P352-P304+P340-P362-P370+P378-P405-P501

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Computational Chemistry Data

  • TPSA   21.26
  • LogP   2.3701
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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