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Structure of 2059963-66-3
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cis-3,5-Dimethyl-4,4-difluoropiperidine is a sterically hindered, bench-stable piperidine derivative featuring two methyl groups at the 3- and 5-positions and two fluorine atoms at the 4-position. This configuration imparts enhanced metabolic stability and modulates basicity, enabling efficient incorporation into bioactive molecules. The cis stereochemistry ensures optimal conformational rigidity for target engagement in medicinal chemistry applications.
cis-3,5-Dimethyl-4,4-difluoropiperidine serves as a conformationally restricted, sterically defined building block for medicinal chemistry applications. The 4,4-difluoro substitution enhances metabolic stability and modulates basicity, while the cis-3,5-dimethyl configuration enforces a defined ring pucker. It functions effectively in amine coupling reactions and facilitates the construction of complex heterocyclic scaffolds with improved pharmacokinetic profiles.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: