Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

Ethyl trimethylsilyldifluoroacetate

  • CAS No. 205865-67-4

  • Cat. No. CS-0121310
  • Purity≥97%
  • MDL No.MFCD04973092

*For research and further manufacturing use only, not for direct human use.

Ethyl trimethylsilyldifluoroacetate|CS-0121310

Structure of 205865-67-4

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 205865-67-4
  • Cat. No. CS-0121310
  • Purity ≥97%
  • MDL No. MFCD04973092
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₄F₂O₂Si
  • Molecular Weight None
  • Synonym(s) Ethyl difluoro(trimethylsilyl)acetate
  • SMILES O=C(OCC)C(F)([Si](C)(C)C)F

Description

Ethyl trimethylsilyldifluoroacetate features a stabilizing trimethylsilyl group that enhances handling and shelf stability. This reagent integrates readily into fluorinated building blocks, enabling efficient access to difluoromethylated synthons under mild reaction conditions.

Application

Ethyl trimethylsilyldifluoroacetate serves as a stable, bench-ready synthon for introducing difluoromethyl groups into complex molecules. It functions as a versatile building block in nucleophilic fluorination and C–H functionalization reactions, enabling efficient access to fluorinated carbonyl derivatives and heterocyclic scaffolds. The trimethylsilyl group enhances stability and facilitates purification, while the ester moiety supports downstream transformations in medicinal chemistry and agrochemical synthesis.

Synthesis

  • Route1
    • null|null
      75-77-4
    • null|null
      383-63-1
    • ~61%
    • In-stock
      Ethyl trimethylsilyldifluoroacetate|CS-0121310
      205865-67-4

    References

    • Utsumi, Shinya; Katagiri, Toshimasa; Uneyama, Kenji Tetrahedron, 2012 , vol. 68, # 2 p. 580 - 583
  • Route2
    • null|null
      75-77-4
    • null|null
      667-27-6
    • ~54%
    • In-stock
      Ethyl trimethylsilyldifluoroacetate|CS-0121310
      205865-67-4

    References

    • Levin, Vitalij V.; Elkin, Pavel K.; Struchkova, Marina I.; Dilman, Alexander D. Journal of Fluorine Chemistry, 2013 , vol. 154, p. 43 - 46
  • Route3
    • null|null
      75-77-4
    • null|null
      383-62-0
    • ~70%
    • In-stock
      Ethyl trimethylsilyldifluoroacetate|CS-0121310
      205865-67-4

    References

    • Fujikawa, Kenichi; Fujioka, Yasutaka; Kobayashi, Akira; Amii, Hideki Organic Letters, 2011 , vol. 13, # 20 p. 5560 - 5563

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05,GHS07
Signal Word : Danger
UN#: 2924
Class : 3,8
Packing Group : Ⅱ
Hazard Statements : H225-H315-H318-H335
Precautionary Statements : P210-P240-P241-P280-P370+P378

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   26.3
  • LogP   2.0622
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   3

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • Ethyl trimethylsilyldifluoroacetate sigmaEthyl trimethylsilyldifluoroacetate manufacturerEthyl trimethylsilyldifluoroacetate priceEthyl trimethylsilyldifluoroacetate structureEthyl trimethylsilyldifluoroacetate SDSbuy Ethyl trimethylsilyldifluoroacetateEthyl trimethylsilyldifluoroacetate supplierEthyl trimethylsilyldifluoroacetate usesEthyl trimethylsilyldifluoroacetate molecular weightprice of Ethyl trimethylsilyldifluoroacetateEthyl trimethylsilyldifluoroacetate chemical name formula of Ethyl trimethylsilyldifluoroacetate
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label