tert-Butyl (5S)-5-amino-3,3-difluoropiperidine-1-carboxylate

Name: tert-Butyl (5S)-5-amino-3,3-difluoropiperidine-1-carboxylate
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 2055848-76-3
Cat. No. CS-0048509
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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tert-Butyl (5S)-5-amino-3,3-difluoropiperidine-1-carboxylate|CS-0048509

Structure of 2055848-76-3

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Description

tert-Butyl (5S)-5-amino-3,3-difluoropiperidine-1-carboxylate is a stereochemically defined piperidine derivative featuring a bench-stable tert-butoxycarbonyl group and two fluorine atoms at the 3-position. This electron-deficient scaffold enables efficient incorporation into bioactive molecules, particularly in medicinal chemistry campaigns targeting CNS disorders and kinase inhibitors. The (5S) configuration ensures high diastereoselectivity during downstream transformations.

Application

tert-Butyl (5S)-5-amino-3,3-difluoropiperidine-1-carboxylate serves as a stereochemically defined building block for the synthesis of fluorinated piperidine scaffolds prevalent in medicinal chemistry. The tert-butyl carbamate group provides excellent stability and ease of removal under mild acidic conditions, while the 3,3-difluoro substitution enhances metabolic stability and modulates electronic properties. This compound facilitates efficient functionalization at the amino position and enables access to diverse analogs via standard coupling and reductive amination protocols.

General Information

CAS No. 2055848-76-3
Cat. No. CS-0048509
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₁₈F₂N₂O₂
Molecular Weight 236.26
Synonym(s) None
SMILES CC(C)(C)OC(=O)N1C[C@@H](N)CC(F)(F)C1

Computational Chemistry Data

TPSA 55.56
LogP 1.5898
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 0

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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tert-Butyl (5S)-5-amino-3,3-difluoropiperidine-1-carboxylate

CAS No. 2055848-76-3

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