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Structure of 205533-31-9
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4,5-Difluoro-2-hydroxybenzoic acid features a strategically positioned hydroxyl group flanked by two fluorine substituents, enhancing its electron-withdrawing character and enabling robust participation in coupling reactions. This ortho-hydroxybenzoic acid derivative exhibits improved solubility and stability under standard conditions, facilitating direct incorporation into complex molecular architectures.
4,5-Difluoro-2-hydroxybenzoic acid serves as a versatile building block in medicinal chemistry, enabling direct incorporation into bioactive scaffolds via standard esterification, amidation, or Suzuki coupling protocols. The ortho-hydroxyl group facilitates chelation in metal-catalyzed transformations, while the difluoro substitution enhances metabolic stability and modulates electronic properties. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step synthesis workflows.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: