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CS-W001157 4
Total: USD 88.00

Propargyl-PEG8-acid

  • CAS No. 2055014-94-1

  • Cat. No. CS-0107562
  • Purity≥95%
  • MDL No.MFCD28976699

*For research and further manufacturing use only, not for direct human use.

Propargyl-PEG8-acid|CS-0107562

Structure of 2055014-94-1

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General Information

  • CAS No. 2055014-94-1
  • Cat. No. CS-0107562
  • Purity ≥95%
  • MDL No. MFCD28976699
  • Storage -20°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₀H₃₆O₁₀
  • Molecular Weight 436.49
  • Synonym(s) None
  • SMILES C#CCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O

Description

Propargyl-PEG8-acid is a water-soluble, bifunctional linker featuring a terminal alkyne for bioorthogonal conjugation and a carboxylic acid for amine coupling. This modular scaffold enables efficient site-specific labeling in complex biological systems. The eight-ethylene glycol units provide enhanced solubility and reduced non-specific binding, making it ideal for probe synthesis in chemical biology and targeted drug delivery applications.

Application

Propargyl-PEG8-acid serves as a versatile bifunctional linker for conjugation and polymer synthesis, combining the reactivity of a terminal alkyne with a hydrophilic PEG8 spacer and a carboxylic acid handle. Its stability under ambient conditions facilitates handling and purification, while enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) and amide coupling reactions. Ideal for bioconjugation, probe development, and functionalizing nanoparticles or solid supports.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   111.14
  • LogP   0.2271
  • H_Acceptors   9
  • H_Donors   1
  • Rotatable_Bonds   25

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