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N-Boc-N-bis(PEG2-acid)

  • CAS No. 2054339-01-2

  • Cat. No. CS-0115265
  • Purity≥97%
  • MDL No.MFCD29912844

*For research and further manufacturing use only, not for direct human use.

N-Boc-N-bis(PEG2-acid)|CS-0115265

Structure of 2054339-01-2

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General Information

  • CAS No. 2054339-01-2
  • Cat. No. CS-0115265
  • Purity ≥97%
  • MDL No. MFCD29912844
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₉H₃₅NO₁₀
  • Molecular Weight 437.48
  • Synonym(s) None
  • SMILES O=C(O)CCOCCOCCN(C(OC(C)(C)C)=O)CCOCCOCCC(O)=O

Description

N-Boc-N-bis(PEG2-acid) features two PEG2-acid chains tethered to a Boc-protected amine, delivering enhanced solubility and stability in aqueous environments. This bifunctional reagent enables efficient conjugation workflows under standard conditions, particularly valuable in peptide derivatization and bioconjugate synthesis.

Application

N-Boc-N-bis(PEG2-acid) serves as a versatile bifunctional building block for the synthesis of PEGylated peptides and bioconjugates. The Boc-protected amine enables orthogonal handling in multi-step syntheses, while the two terminal PEG2-carboxylic acid groups facilitate efficient coupling to primary amines or surface-bound nucleophiles. This structure offers enhanced solubility, stability, and ease of purification in aqueous and mixed solvent systems, making it ideal for applications requiring controlled conjugation and improved pharmacokinetic profiles.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   141.06
  • LogP   1.2393
  • H_Acceptors   8
  • H_Donors   2
  • Rotatable_Bonds   18

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