Lot numbers can be found on the outside label of a product:
1-(((Tert-butoxycarbonyl)amino)methyl)cyclopropane-1-carboxylic acid
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CAS No. 204376-48-7
- Cat. No. CS-0145213
- Purity≥97%
- MDL No.MFCD04973108
*For research and further manufacturing use only, not for direct human use.
Structure of 204376-48-7
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General Information
- CAS No. 204376-48-7
- Cat. No. CS-0145213
- Purity ≥97%
- MDL No. MFCD04973108
- Storage Store at room temperature
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₁₀H₁₇NO₄
- Molecular Weight 215.25
- Synonym(s) Boc-amcp-OH
- SMILES O=C(C1(CNC(OC(C)(C)C)=O)CC1)O
Description
This cyclopropane derivative features a tert-butoxycarbonyl-protected amino methyl group and a carboxylic acid functionality, enabling direct incorporation into peptide synthesis. The Boc moiety provides stability during storage and handling, while the cyclopropyl scaffold introduces conformational rigidity ideal for bioactive molecule design.
Application
1-(((Tert-butoxycarbonyl)amino)methyl)cyclopropane-1-carboxylic acid serves as a stable, bench-ready building block for peptide and peptidomimetic synthesis. The Boc-protected amino group enables selective deprotection under mild acidic conditions, while the cyclopropane carboxylic acid moiety provides structural rigidity and metabolic stability. Its compatibility with standard coupling protocols and ease of purification make it well-suited for iterative synthesis workflows in medicinal chemistry and API development.
Synthesis
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Route1
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In-stock
6914-79-0 - ~87%
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In-stock
204376-48-7
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139126-45-7
References
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US2002/128185 A1, ;
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Route2
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In-stock
24424-99-5 -
139126-45-7
- ~92%
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In-stock
204376-48-7
References
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Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 3 p. 369 - 374
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Route3
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In-stock
6914-79-0
- ~%
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In-stock
204376-48-7
References
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Bioorganic and Medicinal Chemistry Letters, , vol. 9, # 3 p. 369 - 374
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 75.63
- LogP 1.3759
- H_Acceptors 3
- H_Donors 2
- Rotatable_Bonds 3
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Key Words
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