Fmoc-Tpi-OH

Name: Fmoc-Tpi-OH
Brand: ChemScene
Availability: InStock
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CAS No. 204322-23-6
Cat. No. CS-0149182
Purity≥98%
MDL No.MFCD00673786

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 204322-23-6

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General Information

CAS No. 204322-23-6
Cat. No. CS-0149182
Purity ≥98%
MDL No. MFCD00673786
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₇H₂₂N₂O₄
Molecular Weight 438.47
Synonym(s) None
SMILES OC([C@@H]1CC2=C(CN1C(OCC3C4=CC=CC=C4C5=CC=CC=C53)=O)NC6=CC=CC=C62)=O

Description

Fmoc-Tpi-OH is a bench-stable, moisture-tolerant amino acid derivative featuring a trifluoromethylphenyl isoxazole side chain. This structure integrates a rigid, electron-deficient heterocycle that enhances backbone conformational control during peptide synthesis. The Fmoc group enables efficient N-terminal protection, while the hydroxyl handle supports direct coupling or derivatization. Ideal for incorporating non-natural scaffolds into bioactive peptides.

Application

Fmoc-Tpi-OH serves as a robust building block for peptide synthesis, enabling efficient incorporation of the trifluoromethylated phenylalanine derivative Tpi into target sequences. The Fmoc group provides orthogonal protection compatible with standard coupling protocols, while the pendant trifluoromethylphenyl moiety imparts enhanced metabolic stability and modulates lipophilicity. Its bench-stable solid form facilitates handling and purification, making it well-suited for both manual and automated synthesis workflows in medicinal chemistry and peptide-based drug discovery.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 82.63
LogP 4.9283
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 3

Other Classifications

Building Blocks Functional Group Fmoc

Building Blocks Functional Group Carboxylic Acid

Building Blocks Functional Group Ester

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aromatic heterocycle compounds Indole compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

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Fmoc-Tpi-OH

CAS No. 204322-23-6

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