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CS-W001157 4
Total: USD 88.00

(2,5-Dibromophenyl)acetic acid

  • CAS No. 203314-28-7

  • Cat. No. CS-M3358
  • Purity≥98%
  • MDL No.MFCD02664691

*For research and further manufacturing use only, not for direct human use.

(2,5-Dibromophenyl)acetic acid|CS-M3358

Structure of 203314-28-7

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General Information

  • CAS No. 203314-28-7
  • Cat. No. CS-M3358
  • Purity ≥98%
  • MDL No. MFCD02664691
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆Br₂O₂
  • Molecular Weight 293.94
  • Synonym(s) Benzeneacetic acid, 2,5-dibromo-
  • SMILES BrC1=C(CC(O)=O)C=C(Br)C=C1

Description

(2,5-Dibromophenyl)acetic acid features a dibrominated aromatic core that enhances electronic density and reactivity in cross-coupling applications. This bench-stable derivative integrates readily into complex molecular architectures, offering predictable regiocontrol in synthetic transformations. The carboxylic acid group enables direct functionalization or derivatization under standard conditions.

Application

(2,5-Dibromophenyl)acetic acid serves as a versatile building block for brominated aromatic scaffolds, enabling palladium-catalyzed cross-coupling reactions such as Suzuki and Stille couplings. The dibromo substitution pattern provides orthogonal reactivity for sequential functionalization, while the acetic acid group offers direct handle for derivatization or salt formation. Its bench-stable crystalline form facilitates handling and purification, making it well-suited for iterative synthesis in medicinal chemistry and materials development.

Synthesis

  • Route1
    • 2-(2,5-Dibromophenyl)acetonitrile|CS-0157667
      74533-21-4
    • ~45%
    • In-stock
      (2,5-Dibromophenyl)acetic acid|CS-M3358
      203314-28-7

    References

    • Synlett, , # 17 p. 2525 - 2528
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 49, # 12 p. 3563 - 3580
  • Route3

    References

    • Journal of Medicinal Chemistry, , vol. 49, # 12 p. 3563 - 3580

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   2.8387
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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