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CS-W001157 4
Total: USD 88.00

Cyclopropanecarbothioamide

  • CAS No. 20295-34-5

  • Cat. No. CS-0144906
  • Purity≥98%
  • MDL No.MFCD09469287

*For research and further manufacturing use only, not for direct human use.

Cyclopropanecarbothioamide|CS-0144906

Structure of 20295-34-5

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General Information

  • CAS No. 20295-34-5
  • Cat. No. CS-0144906
  • Purity ≥98%
  • MDL No. MFCD09469287
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₇NS
  • Molecular Weight 101.17
  • Synonym(s) Cyclpropanecarbothioamide
  • SMILES S=C(C1CC1)N

Description

Cyclopropanecarbothioamide features a strained cyclopropyl ring fused to a thiocarbonyl-amide functional group, delivering high reactivity in transition-metal-catalyzed cycloadditions. The rigid scaffold enhances regioselectivity in synthetic transformations, while the thioamide moiety supports stable coordination to palladium and nickel complexes under standard conditions. This compound serves as a key intermediate in heterocycle synthesis and enables efficient access to bioactive thiazole derivatives.

Application

Cyclopropanecarbothioamide serves as a versatile building block in medicinal chemistry, enabling the construction of thioamide-containing heterocycles and peptide mimetics. Its cyclopropyl ring imparts conformational rigidity and enhanced metabolic stability, while the thioamide group offers robust nucleophilicity and compatibility with standard coupling reactions. The compound exhibits excellent bench stability and facilitates straightforward purification, making it well-suited for iterative synthesis workflows in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P301+P310-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   0.6825
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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