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CS-W001157 4
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5-Methyl-2-thiazolemethanol

  • CAS No. 202932-04-5

  • Cat. No. CS-W019147
  • Purity≥97%
  • MDL No.MFCD08060774

*For research and further manufacturing use only, not for direct human use.

5-Methyl-2-thiazolemethanol|CS-W019147

Structure of 202932-04-5

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General Information

  • CAS No. 202932-04-5
  • Cat. No. CS-W019147
  • Purity ≥97%
  • MDL No. MFCD08060774
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₇NOS
  • Molecular Weight 129.18
  • Synonym(s) (5-methylthiazol-2-yl)methanol
  • SMILES OCC1=NC=C(C)S1

Description

5-Methyl-2-thiazolemethanol features a thiazole core with methyl and hydroxymethyl substituents, delivering enhanced solubility and stability in polar solvents. This bench-stable scaffold integrates readily into synthetic routes for bioactive molecules, offering a robust platform for medicinal chemistry applications.

Application

5-Methyl-2-thiazolemethanol serves as a versatile building block in medicinal chemistry, enabling efficient construction of thiazole-based scaffolds. Its pendant alcohol group facilitates derivatization via oxidation, esterification, or ether formation, while the electron-rich thiazole ring supports palladium-catalyzed cross-coupling reactions. The molecule exhibits excellent bench stability and simplifies purification due to its defined polarity profile, making it well-suited for iterative synthesis campaigns.

Synthesis

  • Route1
    • 5-Methylthiazole-2-carbaldehyde|CS-W003454
      13838-78-3
    • ~64%
    • In-stock
      5-Methyl-2-thiazolemethanol|CS-W019147
      202932-04-5

    References

    • Journal of Medicinal Chemistry, , vol. 48, # 5 p. 1367 - 1383

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   33.12
  • LogP   0.94382
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   1

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