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CS-W001157 4
Total: USD 88.00

1-Bromo-3,5-difluoro-2-methoxybenzene

  • CAS No. 202865-59-6

  • Cat. No. CS-W014710
  • Purity≥98%
  • MDL No.MFCD00070754

*For research and further manufacturing use only, not for direct human use.

1-Bromo-3,5-difluoro-2-methoxybenzene|CS-W014710

Structure of 202865-59-6

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General Information

  • CAS No. 202865-59-6
  • Cat. No. CS-W014710
  • Purity ≥98%
  • MDL No. MFCD00070754
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅BrF₂O
  • Molecular Weight 223.01
  • Synonym(s) 2-Bromo-4,6-difluorophenyl methyl ether
  • SMILES COC1=C(F)C=C(F)C=C1Br

Description

1-Bromo-3,5-difluoro-2-methoxybenzene features a trifluorinated aromatic core with strategically positioned bromo and methoxy substituents, enabling selective cross-coupling reactions. The electron-deficient ring enhances reactivity in palladium-catalyzed transformations, while the methoxy group improves solubility and stability under standard conditions. This scaffold delivers precise structural control for advanced pharmaceutical intermediates and functional materials.

Application

1-Bromo-3,5-difluoro-2-methoxybenzene serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its ortho-bromine functionality. The difluoro substitution enhances metabolic stability and modulates electronic properties, while the methoxy group provides a handle for further derivatization. Its bench-stable nature and compatibility with diverse reaction conditions make it well-suited for iterative synthesis of complex heterocyclic scaffolds and functionalized aromatic systems.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   9.23
  • LogP   2.7359
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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