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CS-W001157 4
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Diethyl (thiophen-2-ylmethyl)phosphonate

  • CAS No. 2026-42-8

  • Cat. No. CS-0040427
  • Molecule weight234.25
  • Purity≥95%
  • MDL No.MFCD00128457

*For research and further manufacturing use only, not for direct human use.

Diethyl (thiophen-2-ylmethyl)phosphonate|CS-0040427

Structure of 2026-42-8

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General Information

  • CAS No. 2026-42-8
  • Cat. No. CS-0040427
  • Purity ≥95%
  • MDL No. MFCD00128457
  • Storage 4°C, protect from light, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₅O₃PS
  • Molecular Weight 234.25
  • Synonym(s) phosphonic acid, P-(2-thienylmethyl)-, diethyl ester
  • SMILES O=P(CC1=CC=CS1)(OCC)OCC

Description

Diethyl (thiophen-2-ylmethyl)phosphonate features a thiophene-appended phosphonate moiety that integrates readily into C–P bond formation strategies. The electron-rich thiophene ring enhances reactivity in transition-metal-catalyzed coupling processes, while the phosphonate group offers stable anchoring for subsequent transformations. This compound serves as a key building block in synthesizing functionalized organophosphorus architectures with defined stereochemical control.

Application

Diethyl (thiophen-2-ylmethyl)phosphonate serves as a versatile building block in synthetic organic chemistry, enabling the construction of thiophene-containing phosphonate derivatives via standard Pudovik or Horner-Wadsworth-Emmons reactions. Its bench-stable nature and compatibility with diverse functional groups facilitate efficient access to bioactive heterocyclic scaffolds and phosphonate-based intermediates for medicinal chemistry applications.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   35.53
  • LogP   3.5142
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   6

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