1-Bromo-3-chloro-2,4-difluorobenzene

Name: 1-Bromo-3-chloro-2,4-difluorobenzene
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 201849-13-0
Cat. No. CS-0134617
Purity≥97%
MDL No.MFCD00142590

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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1-Bromo-3-chloro-2,4-difluorobenzene|CS-0134617

Structure of 201849-13-0

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General Information

CAS No. 201849-13-0
Cat. No. CS-0134617
Purity ≥97%
MDL No. MFCD00142590
Storage 4°C, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₂BrClF₂
Molecular Weight 227.43
Synonym(s) 1-BROMO-3-CHLORO-2
SMILES FC1=CC=C(Br)C(F)=C1Cl

Description

1-Bromo-3-chloro-2,4-difluorobenzene features a uniquely substituted aromatic ring enabling precise coupling reactions in pharmaceutical synthesis. The strategic placement of bromo, chloro, and difluoro groups facilitates selective cross-coupling under mild conditions. This electron-deficient aryl halide offers enhanced stability and predictable reactivity, streamlining access to complex fluorinated scaffolds in medicinal chemistry workflows.

Application

1-Bromo-3-chloro-2,4-difluorobenzene serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The strategic placement of bromo, chloro, and difluoro substituents provides orthogonal functionalization potential, facilitates selective transformations, and enhances metabolic stability in target scaffolds. Its bench-stable nature and compatibility with standard reaction conditions make it ideal for multi-step synthetic sequences.

Synthesis

Route1
- In-stock
  
  348-57-2
- ~%
- In-stock
  
  201849-13-0
References
- THE PROCTER and GAMBLE COMPANY Patent: WO2004/14893 A2, 2004 ; Location in patent: Page 79 ;
Route2
- In-stock
  
  348-57-2
- 116-16-5
- ~%
- In-stock
  
  201849-13-0
References
- The Procter and Gamble Co. Patent: US6329391 B1, 2001 ;
Route3
- 109-72-8
- In-stock
  
  348-57-2
- 108-18-9
- ~%
- In-stock
  
  201849-13-0
References
- The Procter and Gamble Co. Patent: US6348624 B1, 2002 ; Location in patent: Page column 10 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 0
LogP 3.3807
H_Acceptors 0
H_Donors 0
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Functional Group Bromide

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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1-Bromo-3-chloro-2,4-difluorobenzene

CAS No. 201849-13-0

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