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CS-W001157 4
Total: USD 88.00

N-[(Phenylmethoxy)carbonyl]-L-leucine

  • CAS No. 2018-66-8

  • Cat. No. CS-B1638
  • Purity≥95%
  • MDL No.MFCD00026494

*For research and further manufacturing use only, not for direct human use.

N-[(Phenylmethoxy)carbonyl]-L-leucine|CS-B1638

Structure of 2018-66-8

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General Information

  • CAS No. 2018-66-8
  • Cat. No. CS-B1638
  • Purity ≥95%
  • MDL No. MFCD00026494
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₉NO₄
  • Molecular Weight None
  • Synonym(s) None
  • SMILES CC(C)C[C@@H](C(O)=O)NC(OCC1=CC=CC=C1)=O

Description

N-[(Phenylmethoxy)carbonyl]-L-leucine serves as a protected amino acid derivative, featuring a benzyloxycarbonyl (Cbz) group that stabilizes the α-amino functionality during peptide synthesis. The leucine side chain provides hydrophobic character and steric bulk, enhancing solubility in organic solvents while maintaining compatibility with standard coupling protocols. This derivative streamlines N-terminal protection in sequence assembly.

Application

N-[(Phenylmethoxy)carbonyl]-L-leucine serves as a robust amino acid building block for peptide synthesis, offering enhanced stability and ease of handling. Its benzyloxycarbonyl (Z) protecting group enables selective N-terminal protection with high compatibility across standard coupling protocols. The molecule exhibits excellent functional group tolerance and facilitates efficient deprotection under mild hydrogenolysis conditions, enabling straightforward access to target peptides and peptidomimetics.

Safety Information

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GHS Pictogram :
GHS No : GHS02,GHS08
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H351-H361
Precautionary Statements : P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378-P403+P235-P501

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   2.4121
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   6

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