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CS-W001157 4
Total: USD 88.00

4,5-Dichloro-2-methoxybenzoic acid

  • CAS No. 201150-65-4

  • Cat. No. CS-0150484
  • Purity≥98%
  • MDL No.MFCD11045611

*For research and further manufacturing use only, not for direct human use.

4,5-Dichloro-2-methoxybenzoic acid|CS-0150484

Structure of 201150-65-4

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General Information

  • CAS No. 201150-65-4
  • Cat. No. CS-0150484
  • Purity ≥98%
  • MDL No. MFCD11045611
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₆Cl₂O₃
  • Molecular Weight 221.04
  • Synonym(s) None
  • SMILES COC1=CC(=C(C=C1C(=O)O)Cl)Cl

Description

4,5-Dichloro-2-methoxybenzoic acid features a highly electron-deficient aromatic core flanked by two chlorine substituents and a methoxy group, enabling robust coupling reactions. This bench-stable derivative integrates readily into complex synthetic sequences requiring halogenated aryl motifs.

Application

4,5-Dichloro-2-methoxybenzoic acid serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted heterocycles and bioactive scaffolds. Its orthogonal functional groups—two chlorine atoms and a methoxy group—facilitate selective derivatization via palladium-catalyzed cross-coupling and nucleophilic aromatic substitution. The carboxylic acid moiety supports direct amide formation or esterification, enhancing synthetic flexibility for API development. Bench-stable and readily purified by recrystallization, it functions reliably in multi-step synthesis workflows.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   46.53
  • LogP   2.7002
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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