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CS-W001157 4
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6-Chloro-1-hexanol

  • CAS No. 2009-83-8

  • Cat. No. CS-B1599
  • Purity≥98%
  • MDL No.MFCD00002984

*For research and further manufacturing use only, not for direct human use.

6-Chloro-1-hexanol|CS-B1599

Structure of 2009-83-8

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General Information

  • CAS No. 2009-83-8
  • Cat. No. CS-B1599
  • Purity ≥98%
  • MDL No. MFCD00002984
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₁₃ClO
  • Molecular Weight 136.62
  • Synonym(s) 1-Chloro-6-hexanol; 1-Chloro-6-hydroxyhexane; 6-Chlorohexanol
  • SMILES ClCCCCCCO

Description

6-Chloro-1-hexanol is a functionalized alkyl halide featuring a primary alcohol and terminal chloro group. This bifunctional scaffold enables direct coupling in synthesis, offering enhanced reactivity for derivatization. The molecule exhibits favorable solubility in polar organic solvents and demonstrates stability under standard handling conditions.

Application

6-Chloro-1-hexanol serves as a versatile bifunctional building block, enabling efficient synthesis of linear alkyl chains with orthogonal reactivity. The primary alcohol facilitates coupling reactions and derivatization, while the terminal chloride supports nucleophilic substitution, Mitsunobu transformations, or transition-metal-catalyzed cross-couplings. Its bench-stable nature and compatibility with common protecting group strategies make it well-suited for iterative synthesis in medicinal chemistry and materials development.

Synthesis

  • Route1

    References

    • Li, Le; Herzon, Seth B. Journal of the American Chemical Society, 2012 , vol. 134, # 42 p. 17376 - 17379,4 Title/Abstract Full Text Show Details Li, Le; Herzon, Seth B. Journal of the American Chemical Society, 2012 , vol. 134, # 42 p. 17376 - 17379
  • Route2

    References

    • Khusnutdinov; Shchadneva; Burangulova; Muslimov; Dzhemilev Russian Journal of Organic Chemistry, 2006 , vol. 42, # 11 p. 1615 - 1621
  • Route3
    • tert-Butyl((6-chlorohexyl)oxy)dimethylsilane|CS-1697777
      59431-24-2
    • ~96%
    • In-stock
      6-Chloro-1-hexanol|CS-B1599
      2009-83-8

    References

    • Iida, Akira; Okazaki, Hiroki; Misaki, Tomonori; Sunagawa, Makoto; Sasaki, Akira; Tanabe, Yoo Journal of Organic Chemistry, 2006 , vol. 71, # 14 p. 5380 - 5383

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H312+H332-H315-H319
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P501

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.7779
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   5

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