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Diethyl (4-aminobenzyl)phosphonate

  • CAS No. 20074-79-7

  • Cat. No. CS-0132412
  • Purity≥98%
  • MDL No.MFCD00007913

*For research and further manufacturing use only, not for direct human use.

Diethyl (4-aminobenzyl)phosphonate|CS-0132412

Structure of 20074-79-7

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General Information

  • CAS No. 20074-79-7
  • Cat. No. CS-0132412
  • Purity ≥98%
  • MDL No. MFCD00007913
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₈NO₃P
  • Molecular Weight 243.24
  • Synonym(s) Diethyl 4-aminobenzylphosphonate
  • SMILES O=P(OCC)(CC1=CC=C(N)C=C1)OCC

Description

5'-O-(4,4-Dimethoxytrityl)-2'-OMe inosine-3'-CED phosphoramidite is a 2'-OMe inodine phosphoramidite that can polymerize to form DNA, RNA, or ribonucleosides.

Synthesis

  • Route1

    References

    • ARDELYX, INC.; CHARMOT, Dominique; JACOBS, Jeffrey, W.; LEADBETTER, Michael, Robert; NAVRE, Marc; CARRERAS, Chris; BELL, Noah Patent: WO2010/78449 A2, 2010 ; Location in patent: Page/Page column 152 ; WO 2010/078449 A2
  • Route2

    References

    • Journal of the American Chemical Society, , vol. 81, p. 3026,3029
  • Route3
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    • Diethyl (4-aminobenzyl)phosphonate|CS-0132412
      20074-79-7

    References

    • Journal of Medicinal Chemistry, , vol. 52, # 10 p. 3317 - 3327

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P233-P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

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Computational Chemistry Data

  • TPSA   61.55
  • LogP   3.0349
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   6

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