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CS-W001157 4
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Fmoc-D-Gln(Trt)-OH

  • CAS No. 200623-62-7

  • Cat. No. CS-W011430
  • Purity≥95%
  • MDL No.MFCD00151924

*For research and further manufacturing use only, not for direct human use.

Fmoc-D-Gln(Trt)-OH|CS-W011430

Structure of 200623-62-7

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General Information

  • CAS No. 200623-62-7
  • Cat. No. CS-W011430
  • Purity ≥95%
  • MDL No. MFCD00151924
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₃₉H₃₄N₂O₅
  • Molecular Weight 610.70
  • Synonym(s) None
  • SMILES O=C(CC[C@@H](NC(OCC1C2=CC=CC=C2C3=CC=CC=C13)=O)C(O)=O)NC(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6

Description

Fmoc-D-Gln(Trt)-OH is a protected amino acid derivative designed for solid-phase peptide synthesis. The Fmoc group enables orthogonal deprotection under mild base conditions, while the Trt side chain protection ensures stability during coupling steps. This configuration supports efficient incorporation of D-glutamine into challenging sequences, particularly in bioactive peptides requiring resistance to enzymatic degradation.

Application

Fmoc-D-Gln(Trt)-OH serves as a key building block in peptide synthesis, enabling the incorporation of D-glutamine with orthogonal side-chain protection. The Trt group on the glutamine amide function provides stable protection under standard Fmoc-based conditions, while the Fmoc moiety allows for efficient deprotection via mild base treatment. This combination facilitates reliable coupling and purification in solid-phase synthesis, particularly valuable for constructing complex peptides containing labile or sensitive motifs.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   104.73
  • LogP   6.8668
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   11

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