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CS-W001157 4
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Spiro[2.3]hexan-5-one

  • CAS No. 20061-22-7

  • Cat. No. CS-0048698
  • Purity≥97%
  • MDL No.MFCD23884029

*For research and further manufacturing use only, not for direct human use.

Spiro[2.3]hexan-5-one|CS-0048698

Structure of 20061-22-7

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General Information

  • CAS No. 20061-22-7
  • Cat. No. CS-0048698
  • Purity ≥97%
  • MDL No. MFCD23884029
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₈O
  • Molecular Weight 96.13
  • Synonym(s) Spirohexan-5-one
  • SMILES O=C1CC2(CC2)C1

Description

Spiro[2.3]hexan-5-one delivers a rigid, strained bicyclic scaffold ideal for probing conformational effects in synthetic and medicinal chemistry. The ketone functionality enables direct functionalization, while the spiro architecture imparts unique stereochemical control. This framework integrates seamlessly into molecular designs requiring defined spatial orientation and enhanced metabolic stability.

Application

Spiro[2.3]hexan-5-one serves as a rigid, bicyclic scaffold enabling the construction of diverse heterocyclic systems and bioactive molecules. Its spirocyclic core provides enhanced conformational control, while the ketone functionality offers direct handle for nucleophilic additions, reductions, and derivatization. The compound exhibits excellent bench stability and facilitates straightforward purification, making it a practical building block in medicinal chemistry and natural product synthesis workflows.

Synthesis

  • Route1
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      20440-61-3
    • ~%
    • In-stock
      Spiro[2.3]hexan-5-one|CS-0048698
      20061-22-7

    References

    • Gore,J. et al. Bulletin de la Societe Chimique de France, 1968 , p. 2432 - 2437
  • Route2
    • null|null
      20054-18-6
    • ~%
    • In-stock
      Spiro[2.3]hexan-5-one|CS-0048698
      20061-22-7

    References

    • Gore,J. et al. Bulletin de la Societe Chimique de France, 1968 , p. 2432 - 2437
  • Route3
    • null|null
      20054-17-5
    • ~%
    • In-stock
      Spiro[2.3]hexan-5-one|CS-0048698
      20061-22-7

    References

    • Gore,J. et al. Bulletin de la Societe Chimique de France, 1968 , p. 2432 - 2437

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS07
Signal Word : Danger
UN#: 1224
Class : 3
Packing Group : Ⅲ
Hazard Statements : H225-H315-H319-H335
Precautionary Statements : P210-P233-P240-P241-P242-P243-P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P370+P378-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   1.1295
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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