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CS-W001157 4
Total: USD 88.00

Tetraisopropyl orthosilicate

  • CAS No. 1992-48-9

  • Cat. No. CS-0196958
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Tetraisopropyl orthosilicate|CS-0196958

Structure of 1992-48-9

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General Information

  • CAS No. 1992-48-9
  • Cat. No. CS-0196958
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₈O₄Si
  • Molecular Weight 264.43
  • Synonym(s) tetrapropan-2-yl orthosilicate
  • SMILES CC(C)O[Si](OC(C)C)(OC(C)C)OC(C)C

Description

N,N,3,5-Tetramethylaniline was used in rapid quenching of 1,8-dihydroxyanthraquinone (DHAQ). It was also used as a catalyst in the polymeric synthesis of glycol methacrylate.

Application

Tetraisopropyl orthosilicate serves as a stable, bench-friendly silane source for Si–O bond formation, enabling efficient silylation of alcohols, amines, and carboxylic acids under mild conditions. Its low hydrolytic sensitivity and ease of purification make it ideal for protecting group strategies in complex molecule synthesis. Functions reliably in standard anhydrous organic protocols and supports orthogonal protection schemes in multi-step synthetic sequences.

Synthesis

  • Route1
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      67-63-0
    • ~%
    • In-stock
      Tetraisopropyl orthosilicate|CS-0196958
      1992-48-9

    References

    • Chalmers Doktorsavhandl., , # 6 p. 39,40
  • Route2
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      18145-76-1
    • ~%
    • In-stock
      Tetraisopropyl orthosilicate|CS-0196958
      1992-48-9

    References

    • Journal of Organic Chemistry, , vol. 25, p. 435 - 439
  • Route3
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      541-42-4
    • ~%
    • In-stock
      Tetraisopropyl orthosilicate|CS-0196958
      1992-48-9

    References

    • DE459738 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 16, p. 124

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05
Signal Word : Danger
UN#: 1760
Class : 8
Packing Group : Ⅲ
Hazard Statements : H314
Precautionary Statements : P260-P264-P280-P301+P330+P331-P304+P340-P363-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   36.92
  • LogP   3.122
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   8

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