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CS-W001157 4
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2-Ethyl-2-methylbutanoic acid

  • CAS No. 19889-37-3

  • Cat. No. CS-0217822
  • Molecule weight130.18
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

2-Ethyl-2-methylbutanoic acid|CS-0217822

Structure of 19889-37-3

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General Information

  • CAS No. 19889-37-3
  • Cat. No. CS-0217822
  • Purity ≥98%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₄O₂
  • Molecular Weight 130.18
  • Synonym(s) 2-Methyl-2-ethylbutyric acid
  • SMILES CCC(C)(CC)C(=O)O

Description

2-Ethyl-2-methylbutanoic acid features a sterically hindered α-carbon that enhances its resistance to decarboxylation and oxidation under standard conditions. This structural rigidity supports its use in controlled synthetic pathways, particularly where stability of the carboxylic acid moiety is critical.

Application

2-Ethyl-2-methylbutanoic acid serves as a valuable chiral building block in synthetic organic chemistry, offering a sterically hindered aliphatic carboxylic acid functionality. Its branched alkyl structure enhances metabolic stability and provides a robust scaffold for peptide mimetics and bioactive molecule synthesis. The compound exhibits good bench stability and facilitates efficient coupling reactions with minimal racemization, enabling straightforward incorporation into complex architectures via standard amide bond formation protocols.

Synthesis

  • Route1
    • null|null
      97-95-0
    • ~%
    • In-stock
      2-Ethyl-2-methylbutanoic acid|CS-0217822
      19889-37-3

    References

    • Journal of the American Chemical Society, , vol. 72, p. 4550
  • Route2
    • Ethyl 2-ethyl-2-methylbutanoate|CS-0751976
      19945-14-3
    • ~63%
    • In-stock
      2-Ethyl-2-methylbutanoic acid|CS-0217822
      19889-37-3

    References

    • Chuit, C.; Foulon, J. P.; Normant, J. F. Tetrahedron, 1980 , vol. 36, # 91 p. 2305 - 2310
  • Route3
    • null|null
      592-41-6
    • null|null
      201230-82-2
    • ~24%
    • In-stock
      2-Ethyl-2-methylbutanoic acid|CS-0217822
      19889-37-3
    • In-stock
      2,2-Dimethylvaleric acid|CS-0205424
      1185-39-3

    References

    • Journal of Organic Chemistry, , vol. 65, # 5 p. 1540 - 1543

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.8973
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   3

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