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CS-W001157 4
Total: USD 88.00

H-D-Phg-OMe.HCl

  • CAS No. 19883-41-1

  • Cat. No. CS-W015540
  • Purity≥97%
  • MDL No.MFCD00137487

*For research and further manufacturing use only, not for direct human use.

H-D-Phg-OMe.HCl|CS-W015540

Structure of 19883-41-1

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General Information

  • CAS No. 19883-41-1
  • Cat. No. CS-W015540
  • Purity ≥97%
  • MDL No. MFCD00137487
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₂ClNO₂
  • Molecular Weight None
  • Synonym(s) None
  • SMILES COC([C@H](N)C1=CC=CC=C1)=O.Cl

Description

H-D-Phg-OMe.HCl features a stable, bench-ready D-phenylglycine methyl ester core with enhanced solubility in polar solvents. This protected amino acid derivative integrates seamlessly into peptide synthesis workflows, offering reliable coupling efficiency and minimal side-reaction risk under standard conditions.

Application

H-D-Phg-OMe·HCl serves as a stable, bench-ready building block for peptide synthesis, enabling efficient incorporation of the D-phenylglycine methyl ester moiety. Its hydrochloride salt enhances solubility and handling, while the protected amine and ester groups offer orthogonal reactivity in standard coupling protocols. Functions reliably in solid-phase and solution-phase workflows, facilitating access to bioactive peptidomimetics and macrocyclic scaffolds.

Synthesis

  • Route1
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      67-56-1
    • H-D-Phg-OH Ampicillin Impurity|CS-0229771
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    • In-stock
      H-D-Phg-OMe.HCl|CS-W015540
      19883-41-1

    References

    • Davies, Stephen G.; Sanganee, Hitesh J.; Szolcsanyi, Peter Tetrahedron, 1999 , vol. 55, # 11 p. 3337 - 3354
  • Route2

    References

    • Journal of the American Chemical Society, , vol. 128, # 19 p. 6304 - 6305
  • Route3
    • null|null
      67-56-1
    • In-stock
      (αR)-α-[[(1,1-Dimethylethoxy)carbonyl]amino]benzeneacetic acid|CS-W020686
      33125-05-2
    • ~91%
    • In-stock
      H-D-Phg-OMe.HCl|CS-W015540
      19883-41-1

    References

    • Chen, Bang-Chi; Skoumbourdis, Amanda P.; Guo, Peng; Bednarz, Mark S.; Kocy, Octavian R.; Sundeen, Joseph E.; Vite, Gregory D. Journal of Organic Chemistry, 1999 , vol. 64, # 25 p. 9294 - 9296

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   52.32
  • LogP   1.2812
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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