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Fmoc-D-Chg-OH

  • CAS No. 198543-96-3

  • Cat. No. CS-0149819
  • Purity≥98%
  • MDL No.MFCD00190877

*For research and further manufacturing use only, not for direct human use.

Fmoc-D-Chg-OH|CS-0149819

Structure of 198543-96-3

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General Information

  • CAS No. 198543-96-3
  • Cat. No. CS-0149819
  • Purity ≥98%
  • MDL No. MFCD00190877
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₃H₂₅NO₄
  • Molecular Weight 379.45
  • Synonym(s) (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-cyclohexylacetic acid
  • SMILES O=C(O)[C@H](NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)C4CCCCC4

Description

Fmoc-D-Chg-OH is a bench-stable, moisture-tolerant amino acid derivative featuring a D-configured choline moiety. This polar, zwitterionic side chain enhances solubility in aqueous and mixed solvents while maintaining compatibility with standard peptide synthesis protocols. The Fmoc group enables efficient N-terminal protection, streamlining incorporation into complex sequences.

Application

Fmoc-D-Chg-OH serves as a key building block in peptide synthesis, enabling the incorporation of D-3-chloro-homoglutamine residues with high stability and ease of purification. The Fmoc group provides robust protection for the α-amino function, facilitating efficient coupling and orthogonal deprotection. Its chlorinated side chain offers enhanced metabolic stability and can serve as a site for downstream functionalization, making it valuable in the construction of bioactive peptides and peptidomimetics.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   4.5586
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   5

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