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CS-W001157 4
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2-Methyl-1-(naphthalen-2-yl)propan-2-amine

  • CAS No. 198226-63-0

  • Cat. No. CS-M0687
  • Purity≥95%
  • MDL No.MFCD11519113

*For research and further manufacturing use only, not for direct human use.

2-Methyl-1-(naphthalen-2-yl)propan-2-amine|CS-M0687

Structure of 198226-63-0

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General Information

  • CAS No. 198226-63-0
  • Cat. No. CS-M0687
  • Purity ≥95%
  • MDL No. MFCD11519113
  • Storage RT, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₄H₁₇N
  • Molecular Weight None
  • Synonym(s) 2-Methyl-1-(2-naphthyl)propan-2-amine
  • SMILES NC(C)(C)CC1=CC2=CC=CC=C2C=C1

Description

2-Methyl-1-(naphthalen-2-yl)propan-2-amine features a sterically hindered tertiary amine core linked to a naphthalene moiety, delivering enhanced stability and electron-donating character. This structure enables efficient coordination in catalytic systems and facilitates incorporation into functionalized organic frameworks under standard conditions.

Application

2-Methyl-1-(naphthalen-2-yl)propan-2-amine serves as a versatile chiral building block in medicinal chemistry, enabling the synthesis of bioactive scaffolds through standard amine functionalization. Its tertiary amine functionality exhibits excellent bench stability and compatibility with common coupling reactions, facilitating efficient derivatization. The naphthalene moiety provides a rigid, hydrophobic domain useful in modulating target binding affinity and metabolic stability in drug discovery campaigns.

Synthesis

  • Route1
    • null|null
      400613-92-5
    • ~%
    • In-stock
      2-Methyl-1-(naphthalen-2-yl)propan-2-amine|CS-M0687
      198226-63-0

    References

    • Kamal, Ahmed; Chouhan, Gagan Tetrahedron Asymmetry, 2005 , vol. 16, # 16 p. 2784 - 2789
  • Route2
    • null|null
      1401437-15-7
    • ~%
    • In-stock
      2-Methyl-1-(naphthalen-2-yl)propan-2-amine|CS-M0687
      198226-63-0

    References

    • US2012/252802 A1, ; Page/Page column 78-79 ; US 20120252802 A1
  • Route3
    • null|null
      211871-56-6
    • ~%
    • In-stock
      2-Methyl-1-(naphthalen-2-yl)propan-2-amine|CS-M0687
      198226-63-0

    References

    • US2004/6130 A1, ; Page 21 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   26.02
  • LogP   3.1196
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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