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CS-W001157 4
Total: USD 88.00

2,2'-(1,3-Phenylene)diacetic acid

  • CAS No. 19806-17-8

  • Cat. No. CS-0199635
  • Purity≥98%
  • MDL No.MFCD00004341

*For research and further manufacturing use only, not for direct human use.

2,2'-(1,3-Phenylene)diacetic acid|CS-0199635

Structure of 19806-17-8

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General Information

  • CAS No. 19806-17-8
  • Cat. No. CS-0199635
  • Purity ≥98%
  • MDL No. MFCD00004341
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₀H₁₀O₄
  • Molecular Weight 194.19
  • Synonym(s) m-Phenylenediacetic acid
  • SMILES O=C(O)CC1=CC=CC(=C1)CC(=O)O

Description

This diacid features a rigid phenylene linker that imparts structural stability and enhances solubility in polar solvents. The carboxylic acid groups enable straightforward derivatization for conjugation or metal coordination, making it valuable in supramolecular chemistry and polymer synthesis.

Application

2,2'-(1,3-Phenylene)diacetic acid serves as a versatile diacid building block for constructing rigid, aromatic scaffolds in medicinal chemistry and materials science. Its ortho-substituted phenylene core enables efficient coupling reactions, while the carboxylic acid groups offer straightforward derivatization and metal chelation potential. The compound exhibits good bench stability and facilitates purification via crystallization or standard chromatographic methods, making it well-suited for iterative synthesis workflows.

Synthesis

  • Route1

    References

    • De Koning, Pieter D.; Gladwell, Iain R.; Morrison, Natalie A.; Moses, Ian B.; Panesar, Maninder S.; Pettman, Alan J.; Thomson, Nicholas M.; Yazbeck, Daniel R. Organic Process Research and Development, 2011 , vol. 15, # 4 p. 871 - 875
  • Route2
    • null|null
      201230-82-2
    • In-stock
      1,3-Bis(chloromethyl)benzene|CS-W017469
      626-16-4
    • ~73%
    • In-stock
      2,2'-(1,3-Phenylene)diacetic acid|CS-0199635
      19806-17-8

    References

    • Terekhova, M. I.; Kron, T. E.; Petrova, N. E.; Petrov, E. S. Journal of Organic Chemistry USSR (English Translation), 1991 , vol. 27, # 11.2 p. 2101 - 2104 Zhurnal Organicheskoi Khimii, 1991 , vol. 27, # 11 p. 2368 - 2371
  • Route3
    • null|null
      108-38-3
    • ~%
    • In-stock
      2,2'-(1,3-Phenylene)diacetic acid|CS-0199635
      19806-17-8

    References

    • Journal of the American Chemical Society, , vol. 65, p. 1339,1345

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   74.6
  • LogP   0.9408
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   4

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